T cell differentiation

involvement of microrna in t-cell differentiation and malignancy.

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

T cell rewiring in differentiation and disease.

Plasticity of CD4+ T cell lineage differentiation.

The differentiation of naive CD4(+) T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-gamma, whereas Th2 cells express IL-4. The discovery and investigation of two other CD4(+) T cell subsets, induced regulatory T (iTreg) cells and Th17 cells, has led to a rethinking of the notion that helper T ...

Notch governing mature T cell differentiation.

The differentiation of naive T cells to effector/memory T cells is regulated by a variety of factors. The recent advance of the contribution of Notch signaling in this differentiation step has provided a new path to better understand the acquisition or persistence of effector function of mature T cells. In this review, we summarize emerging and, in some points, conflicting evidence for Notch si...

Model Analysis of Helper T Cell Differentiation

Helper T (Th) cells regulate immune responses by producing various cytokines upon antigen stimulation. Helper T cells can be divided into two subsets, Th1 and Th2 [2]. The Th1 cells are responsible for defense against infectious intracellular microorganisms. The Th2 cells are responsible for defense against extracellular pathogens and the development of allergic immune reactions. The SOCS famil...